Spurs may be forced to start with their transfer deadline-day acquisition from Everton because of injuries to several forwards.
Jermain Defoe and Emmanuel Adebayor are struggling with hamstring problems while Rafael van der Vaart (calf) and Aaron Lennon (hamstring) are also doubtful.
Defender William Gallas (calf) and midfielder Tom Huddlestone (ankle) are definite absentees but full-back Kyle Walker (groin) and centre-half Ledley King (knee) should be fit.
Liverpool welcome back Luis Suarez following his eight-match ban for racially abusing Manchester United defender Patrice Evra.
While the Uruguay striker is likely to start on the bench, captain Steven Gerrard is available after being rested for the midweek win at Wolves.